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Clinical Studies & Publications

Florastor® Probiotic Clinical and Scientific Studies and Publications
Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis
Probiotics for Antibiotic-Associated Diarrhea: What, When, and How Long?
Prevention and treatment of diarrhoea with Saccharomyces boulardii in children with acute lower respiratory tract infections
The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii
Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea
Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update
Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis
Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease
Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics?
Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers
Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea
Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study
Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition
Efficacy and safety of Saccharomyces boulardii for acute diarrhea
Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties
Recovery and elimination of the biotherapeutic agent, Saccharomyces boulardii, in healthy human volunteers
Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii
Disposition kinetics of Saccharomyces boulardii in man and rat
Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea

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Florastor Safety Warning:

Do not use Florastor or other probiotics in any ICU setting and in those individuals with open arterial and venous access required (such as a Vascath, Permcath, or AV fistula).

Do not use for any individual with a central line or port or in the surroundings of any patient with a central line or port. [Central lines include short- and long-term central venous catheters (CVCs) and peripherally inserted central catheters (PICCs)]

Do not use Florastor for pre- or post- organ or bone marrow transplant patients and other patients considered severely immunocompromised or critically ill.

Do not use Florastor probiotics if allergic to any components (especially yeast).

Very rarely, side effects such as: allergic reaction (skin rash). Fungemia or sepsis in patients with a central venous catheter, and in hospitalized, immunocompromised patients may occur.

For product questions or to report an adverse event, please call (877) 356-7787.

See References
  1. Kabbani TA, Pallav K, Dowd SE, Villafuerte-Galvez J, Vanga RR, Castillo NE, Hansen J, Dennis M, Leffler DA, Kelly CP. Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers. Gut Microbes. 2017 Jan 2;8(1):17-32. doi: 10.1080/19490976.2016.1267890. Epub 2016 Dec 14. PMID: 27973989; PMCID: PMC5341914.
  2. Martins FS, Silva AA, Vieira AT, Barbosa FH, Arantes RM, Teixeira MM, Nicoli JR. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol. 2009 Aug;191(8):623-30. doi: 10.1007/s00203-009-0491-x. Epub 2009 Jun 13. PMID: 19526225.
  3. McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006 Apr;101(4):812-22. doi: 10.1111/j.1572-0241.2006.00465.x. PMID: 16635227.
  4. C, Mahieux S, Dubreuil LJ., Neut C. Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics? Med Mal Infect. 2017 Nov;47(7):477-483. doi: 10.1016/j.medmal.2017.07.001. Epub 2017 Aug 7. PMID: 28797834.
  5. Shan LS et al. Prevention and treatment of diarrhoea with Saccharomyces boulardii in children with lower respiratory tract infections. Beneficial Microbes. 2013;4(4):329-334. doi:10.3920/BM2013.0008.
  6. Surawicz CM, McFarland LV, Greenberg RN, Rubin M, Fekety R, Mulligan ME, Garcia RJ, Brandmarker S, Bowen K, Borjal D, Elmer GW. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis. 2000 Oct;31(4):1012-7. doi: 10.1086/318130. Epub 2000 Oct 25. PMID: 11049785.
  7. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea. Aliment Pharmacol Ther. 2015 Oct;42(7):793-801. doi: 10.1111/apt.13344. Epub 2015 Jul 27. PMID: 26216624.
  8. Szajewska H, Kołodziej M, Zalewski BM. Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update. Aliment Pharmacol Ther. 2020 Apr;51(7):678-688. doi: 10.1111/apt.15659. Epub 2020 Feb 13. PMID: 32056266.
  9. Swidsinski A, Loening-Baucke V, Verstraelen H, Osowska S, Doerffel Y. Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea. Gastroenterology. 2008 Aug;135(2):568-79. doi: 10.1053/j.gastro.2008.04.017. Epub 2008 Apr 18. PMID: 18570896.
  10. Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019 Oct;24(5):e12651. doi: 10.1111/hel.12651. Epub 2019 Aug 14. PMID: 31414551.
  11. Can M et al. Prophylactic Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea: A prospective study. Medical Science Monitor. 2006;12(4):2004-2007.
  12. More MI, Swidsinski A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis - A review. Clinical and Experimental Gastroenterology. 2015;8:237-255. doi:10.2147/CEG.S85574.
  13. Seddik H et al. Saccharomyces boulardii CNCM I-745® plus sequential therapy for Helicobacter pylori infections: a randomized, open-label trial. European Journal of Clinical Pharmacology. 2019;75(5):639-645. doi:10.1007/s00228-019-02625-0.
  14. McFarland, L. V. (2008). Antibiotic-associated diarrhea: epidemiology, trends and treatment. Future Microbiol. 3, 563-578. doi: 10.2217/17460913.3.5.563
  15. Beaugerie, L., Flahault, A., Barbut, F., Atlan, P., Lalande, V., Cousin, P., et al. (2003). Antibiotic-associated diarrhoea and Clostridium difficile in the community. Aliment Pharmacol. Ther. 17,905-912. doi:10.1046/j. 1365-2036.2003.01531.x
  16. Buts, J.P., Bernasconi, P., Van Craynest, M.P., Maldague, P., & De Meyer, R. (1986). Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii. Pediatric Research, 20, 192-196.
  17. Czerucka D, Rampal P. Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections. World journal of gastroenterology. 2019;25(18):2188-2203. doi:10.3748/wjg.v25.i18.2188.
  18. Joly F et al. Saccharomyces boulardii CNCM I-745. In: Marteau P, Dore J, eds. Gut Microbiota: A Full-Fledged Organ. Paris: John Libbey Eurotext; 2017:305-350.
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