Florastor® Reduces the risk of C. difficile-associated disease

Florastor’s proprietary Saccharomyces boulardii CNCM I-745 strain employs a multifaceted approach to degrade the toxins produced by Clostridioides difficile, addressing the root causes of intestinal damage and symptoms.

Florastor provides unique benefits that are supported by systematic reviews and meta-analyses:

  • Antibiotic Resistance: Can be taken directly with antibiotics without impacting bioavailability and efficacy.
  • Toxin Degradation & Modulation: Saccharomyces boulardii CNCM I-745 produces a 54-kDa serine protease that degrades C. difficile toxin A and may help modulate the effects of toxin B, minimizing their harmful impact on the intestinal lining.
  • Receptor Site Blocking & Barrier Protection: Saccharomyces boulardii CNCM I-745 helps prevent C. difficile toxins A and B from binding to intestinal cells and supports intestinal barrier integrity, reducing toxin-mediated damage and inflammation.
  • Inhibition of Toxin Binding: Prevents toxins from adhering to intestinal cells, offering sustained protection after antibiotic therapy, allowing the gut microbiome to recover and rebuild its natural defenses.

Florastor significantly reduces the frequency of recurrent Clostridioides difficile-associated disease in adults

In a double-blind, placebo-controlled trial, Florastor (500mg bid) reduced the frequency of recurrence of CDD when combined with antibiotics by preventing 66.6% (p=0.05) of CDD compared with placebo with antibiotics6.

Florastor significantly reduces the frequency of recurrent Clostridioides difficile-associated disease in children

C. difficile-associated diarrhea: Sub-group diarrhea: Sub-group analysis demonstrated that treatment with Florastor reduced the risk of C. difficile associated diarrhea in children (2 RCTs, n = 579, RR: 0.25, 95% CI: 0.08-0.73.)7.

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